帕克利塔塞尔诱导的周围神经病变的最新观点
Shan Wu1,2, Tu Xiong3, Shenglan Guo4
1Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Journal of cancer research and therapeutics
|December 29, 2023
概括
帕克利塔塞尔诱导的周围神经病变 (PIPN) 是一种常见的化疗副作用,会影响患者的生存和生活质量. 本综述总结了PIPN研究,以改善长期预防和治疗策略.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 是神经毒性化疗剂的常见副作用.
- 帕克利塔塞尔诱导的周围神经病变 (PIPN) 可能会危及患者的生存,因为需要减少或停止化疗剂量.
- 治疗后PIPN症状可能会持续或恶化,导致癌症幸存者长期患病.
研究的目的:
- 审查目前关于PIPN.的临床表现,风险因素和病变发生的研究.
- 探索用于预防和治疗PIPN.的既定和新兴策略.
- 引导未来的研究,以改善PIPN.患者的长期生活质量.
主要方法:
- 对PIPN.的临床前和临床研究进行了全面的文献搜索.
- 对PIPN病因,临床表现和管理的研究结果的综合.
- 对当前治疗方法和未来研究方向的分析.
主要成果:
- PIPN呈现出各种神经症状,包括感官损失,疼痛和运动缺陷.
- 多种风险因素有助于PIPN的发展,受患者特异性和与治疗相关的变量的影响.
- 目前的管理策略具有有限的有效性,突出了对新型干预措施的需求.
结论:
- 有效预防和治疗PIPN对于维持化疗疗效和改善患者治疗结果至关重要.
- 对PIPN病变的进一步研究对于开发有针对性和有效的疗法至关重要.
- 改善幸存者的长期生活质量需要一个多方面的方法来管理PIPN.
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