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场不完美校正对3D-SPARKLING fMRI数据中的BOLD灵敏度的影响

Zaineb Amor¹, Caroline Le Ster¹, Chaithya Gr^1,2

¹CEA, NeuroSpin, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.

Magnetic resonance in medicine

|December 29, 2023

概括

在功能性MRI (fMRI) 中纠正磁场缺陷显著提高了血氧水平依赖 (BOLD) 信号的灵敏度和图像质量. 这种技术提高了BOLD对比度的准确性,在超高场成像中揭示了更多激活的大脑区域.

科学领域:

磁共振成像是一种磁共振成像技术.
神经成像是一种神经成像.
生物物理学的生物物理.

背景情况:

静态和动态磁场的缺陷会降低功能性MRI (fMRI) 的性能,特别是在超高磁场 (UHF) 时.
这些场干扰会对血液中依赖氧气水平 (BOLD) 信号的灵敏度产生负面影响,这是fMRI研究中的关键指标.

研究的目的:

评估回顾性纠正磁场扰动对非卡特西安3D闪光fMRI中的BOLD灵敏度的好处.
评估静态和动态场校正对fMRI图像质量和BOLD信号检测的影响.

主要方法:

采集了1mm分辨率的fMRI数据与2.4s TR,并同时使用Scope Clip-on现场摄像头实时监测现场干扰.
利用动态场偏差测量和静态场地图来追溯纠正场地缺陷.
对健康志愿者进行了比较研究,以评估校正对fMRI体积的影响.

主要成果:

对磁场偏差的纠正改善了图像质量,将时间中位信号对噪声比 (tSNR) 提高了20-30%.
显示了BOLD对比度灵敏度的显著增加和BOLD相位图精度的提高.
在一个视网膜图谱绘图实验中,检索了44%更多的激活声元 (p<0.001,未经校正) 和159%更多 (p<0.05,FDR校正).

结论:

3D-SPARKLING fMRI显著受益于对静态和动态磁场缺陷的纠正.
拟议的实验协议可适应各种编码方案,包括非卡特西亚读数.
这种方法提高了fMRI在超高场的实用性.

关键词:

3D闪闪发光的东西核磁共振 (NMR) 探测器使用功能磁力共振成像 (fMRI) 是一种现场监测现场监测现场监测其他非卡尔特西亚鱼类.

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