在怀孕期间和之后的临床,口腔免疫学和微生物学的转变
Pınar Meriç1, Angelika Silbereisen2, Gülnur Emingil1
1Department of Periodontology, School of Dentistry, Ege University, İzmir, Turkey.
Clinical oral investigations
|December 29, 2023
概括
怀孕改变了免疫系统,增加了Th1/Th2细胞因子比率,促进了炎症. 这种转变与牙周病原体有关,表明孕妇具有破坏性炎症特征.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 牙周病学 牙周病学
背景情况:
- 怀孕与T-辅助剂 (Th) 2 主要的细胞因子调节 (抗炎) 有关.
- 怀孕期间口腔健康恶化涉及Th1 (促炎) 细胞因子表型和微生物组变化.
- 这项研究调查了孕妇口腔健康中的免疫和微生物转变.
研究的目的:
- 为了评估T-辅助剂 (Th) 细胞因子在怀孕和产后的转移.
- 分析出生前和出生后唾液中口腔微生物组合的变化.
- 为了确定细胞因子配置和牙周状况之间的关联.
主要方法:
- 对96名女性进行前性观察性研究.
- 在出生前和出生后6个月收集的唾液样本.
- 对10种细胞因子的多重免疫试验和对牙周病原体的定量实时PCR.
主要成果:
- 与分娩后相比,在怀孕期间显著降低Th2和更高的促炎细胞因子水平.
- 在怀孕和产后期间,Th1水平没有显著差异.
- 怀孕期间Th1/Th2细胞因子,牙周参数和细菌水平之间的正相关性.
结论:
- 在怀孕期间显著增加的Th1/Th2细胞因子比率与假定的牙周病原体有关.
- 这种免疫学和微生物学的放松调节表明具有破坏性的炎症性牙周形状.
- 了解这些变化可以改善孕妇牙周健康.
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