同时发生的波纹振荡促进了人类皮层位置之间的神经元相互作用
Ilya A Verzhbinsky1,2, Daniel B Rubin3, Sophie Kajfez4
1Neurosciences Graduate Program, University of California San Diego, La Jolla, CA 92093.
概括
同步的大脑活动,称为,有助于将信息绑定在遥远的皮层区域. 这项研究表明,同时发生的波纹协调神经发射,支持大脑整合理论.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 跨空间分布的神经元的神经元集成对认知至关重要.
- 假设同步的高频振荡或波纹可以促进这种集成.
- 以前的研究表明,波调节局部皮质活动,但远程协调仍然不清楚.
研究的目的:
- 为了调查是否同时发生的波纹协调神经元在遥远的皮层位置的发射.
- 为了测试大规模神经集成的绑定同步假设.
主要方法:
- 在3名患者中使用微电极阵列记录了来自人类上粒状皮层的局部场潜力和单个单元活动.
- 分析神经元发射模式,包括共同发射,预测和参与神经组合,在同时发生的波纹事件期间.
主要成果:
- 在共同的位置上的神经元表现出增加的短延迟共同发射和相互发射预测.
- 这些效应在各种神经元类型,大脑状态 (睡眠/清醒),皮质区域和长达16毫米的距离上观察到.
- 在co-ripples期间的增强预测是相模拟的,与本地活动有协同作用,支持绑定-by-synchrony.
结论:
- 跨皮层同时发生的波纹增强了神经元在不同皮层区域的激发的整合.
- 这种集成部分通过相调节的同步而不是简单的激活来实现.
- 这些发现支持同步波纹在大规模神经协调和信息结合中的作用.
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