尼尔塞维马布用于预防婴儿因RSV住院
Simon B Drysdale1, Katrina Cathie1, Florence Flamein1
1From the Centre for Neonatal and Paediatric Infections, St. George's, University of London, and the Department of Paediatrics, St. George's University Hospitals National Health Service (NHS) Foundation Trust, London (S.B.D.), the National Institute for Health Research Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, and the Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton (K.C., S.N.F.), the Liverpool Vaccine Group, Liverpool School of Tropical Medicine (A.M.C., H.C.H.), and Liverpool University Hospitals Foundation, NHS Trust (A.M.C.), Liverpool, Sanofi, Reading (C.T.F., N.C.V.), and the University of Nottingham Health Service, University of Nottingham, Nottingham (S.R.) - all in the United Kingdom; Université de Lille, INSERM, Centre Hospitalier Universitaire (CHU) de Lille, CIC-1403 INSERM-CHU, Lille (F.F.), the French Clinical Research Infrastructure Network-PEDSTART, Tours (F.F.), Centre Hospitalier Intercommunal de Créteil, and Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil (R.C.), CHU Rouen, Department of Neonatal Pediatrics and Intensive Care and Neuropediatrics, Charles Nicolle University Hospital, Rouen (D.P.), Sanofi Vaccines, Lyon (M.B., R.N., S.W.), Sanofi Vaccines, Marcy L'Etoile (K.M.), Pediatric Intensive Care, Neonatal Medicine and Pediatric Emergency Department, Assistance Publique-Hôpitaux de Paris, Paris-Saclay University, Bicêtre Hospital, Le Kremlin-Bicêtre (P.T.), and the Institute of Integrative Biology of the Cell, Centre National de la Recherche Scientifique, Commissariat à l'Energie Atomique, Paris-Saclay University, Gif sur Yvette (P.T.) - all in France; Children's Hospital, Worms (M.K.), Pediatric Infectious Diseases, University Medicine, Mainz (M.K.), and Gemeinschaftspraxis für Kinder und Jugendmedizin, Tangstedter Landstrasse 77, Hamburg (F.K.) - all in Germany; Sanofi, Huipu Mansion, Beijing (J.J.); and Sanofi Vaccines, Bridgewater, NJ (M.R.).
尼尔西维玛可显著减少婴儿因呼吸道同胞病毒 (RSV) 下呼吸道感染而住院的病例. 这种单克隆抗体在现实环境中表现出高的疗效和安全性,保护脆弱的婴儿.
科学领域:
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 尼尔塞维马布 (nirsevimab) 是一种单克隆抗体,用于预防健康婴儿的呼吸道同胞病毒 (RSV) 相关的下呼吸道感染 (LRTI) 的安全性和有效性尚未完全确定.
- 需要在现实临床环境中评估nirsevimab对RSV相关住院治疗的影响.
研究的目的:
- 评估nirsevimab在预防RSV相关的婴儿下呼吸道感染住院的疗效.
- 评估尼尔塞维马布在婴儿的第一个RSV季节之前或期间给婴儿的安全性.
主要方法:
- 一项实用随机试验,涉及法国,德国和英国8058名婴儿 (≤12个月).
- 婴儿接受了单次肌肉内注射nirsevimab或标准护理.
- 主要终点:住院治疗RSV相关的LRTI;次要终点:非常严重的RSV相关的LRTI.
主要成果:
- 尼尔塞维马布在与RSV相关的LRTI住院治疗方面表现出83.2%的疗效 (11对60例).
- 对非常严重的RSV相关LRTI的疗效为75.7% (5对19例).
- 与治疗相关的不良事件在nirsevimab组中不常见 (2.1%) .
结论:
- 尼尔塞维马布有效地保护婴儿免受RSV相关的LRTI和非常严重的RSV相关的LRTI的住院治疗.
- 这项研究支持nirsevimab在现实环境中用于婴儿RSV预防的使用.
更多相关视频
相关概念视频
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Upper Respiratory Drugs: First and Second-Generation Antihistamines
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
Common Respiratory Disorders
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Vaccinations


