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在不活跃的原发性进展性多发性硬化症中,残疾恶化的生物标志物

Maria-Elizabeth Baeva¹, Isabelle Tottenham¹, Marcus Koch¹

¹Department of Clinical Neurosciences, University of Calgary, Canada; Hotchkiss Brain Institute, University of Calgary, Canada.

Journal of neuroimmunology

|December 29, 2023

概括

血清生物标志物生长分化因子-15 (GDF-15) 和cathepsin-D可以预测不活跃初级渐进性多发性硬化症 (PPMS) 的疾病恶化. 在基线较高的水平表明未来的残疾进展,即使没有活跃的炎症.

科学领域:

神经免疫学神经免疫学
生物标志物发现发现
神经退行性疾病神经退行性疾病

背景情况:

初级渐进性多发性硬化症 (PPMS) 的特征是逐渐的神经衰退.
在不活跃的PPMS中确定可靠的疾病进展生物标志物对于患者管理和治疗开发至关重要.
目前对PPMS进展的基于血清的预测标志物的理解仍然有限.

结论:

在PPMS患者中存在改变GDF-15,DKK-1和cathepsin-D的血清水平.
GDF-15和cathepsin-D显示出作为PPMS进展的预测生物标志物的潜力,独立于炎症活动.
这些发现可能有助于监测疾病的进展,并识别患有更高进展风险的个体.

关键词:

生物标志物生物标志物在cathepsin-D中使用.DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1,NSE-DKK-1 这是GDF-15的GDF-15.多发性硬化症是多发性硬化症.这是一个PPMSPPMS.

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