减少前白质,有心理疾病的风险,与处理速度相关,作为一种基本的认知障碍
Arndt-Lukas Klaassen1, Chantal Michel1, Miriam Stüble2
1University Hospital of Child and Adolescent Psychiatry and Psychotherapy Bern, University of Bern, Switzerland.
Schizophrenia research
|December 29, 2023
概括
处理速度调解了体白质完整性和临床精神病高风险个体的认知缺陷之间的联系. 这突出了处理速度的速度.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 以前的研究将体白质 (WM) 完整性与精神疾病中的认知功能联系起来.
- 在精神病风险阶段,状肌肉干扰和认知缺陷之间的关系仍未得到充分探索.
研究的目的:
- 为了调查白质 (WM) 完整性在体 (CC) 和认知功能在青少年和年轻成年人临床高风险精神病 (CHR) 之间的关联.
- 确定处理速度是否调解了CC WM完整性与其他认知领域之间的关系.
主要方法:
- 分数异构 (FA) 用于测量60名CHR患者和38名健康对照 (HC) 的CC WM完整性.
- 基于路径的空间统计分析了CC-FA与处理速度,执行功能和空间工作记忆之间的群体差异和关联.
- 调解分析探讨了处理速度在将CC结构与认知表现联系起来的作用.
主要成果:
- 与HC患者相比,CHR患者在处理速度,执行功能和空间工作记忆方面表现出缺陷.
- 在CHR患者中,在CC的基因和体内观察到减少了FA.
- 处理速度调解了CC结构与执行功能和空间工作记忆之间的关联.
结论:
- 处理速度是关键的认知因素,它将大脑体 (CC) 白质完整性与执行功能和工作记忆缺陷联系起来.
- 这些发现扩大了以前关于精神病障碍的研究,将其扩展到精神病前的危险阶段.
更多相关视频
05:52Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
14.9K
08:42Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
Published on: May 19, 2015
10.7K
相关概念视频
Biological Causes of Schizophrenia
58
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
58
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
662
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
662
Attention-Deficit/Hyperactivity Disorder
68
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
68
Psychological and Sociocultural Causes of Schizophrenia
91
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
91
