在精神分裂症和严重抑郁症中,范围适应性值表示.
Ling-Ling Wang1, Simon S Y Lui2, Jane W L So3
1Neuropsychology and applied cognitive neuroscience laboratory; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China; School of Psychology, Shanghai Normal University, Shanghai, China.
Asian journal of psychiatry
|December 29, 2023
概括
精神分裂症和严重抑郁症患者表现出改变的奖励处理,特别是范围适应. 预期值 (EV) 和结果值 (OV) 适应的这些变化与无和无动机有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 无情和无动力是精神分裂症 (SCZ) 和严重抑郁症 (MDD) 的核心症状.
- 奖励处理涉及构建和对比预期值 (EV) 和结果值 (OV) 表示,这一过程称为范围调整.
- 据假设,受损的适应范围有助于无情和无动机.
研究的目的:
- 研究SCZ和MDD个体的范围适应.
- 为了比较SCZ和MDD患者和健康对照之间的范围适应模式.
- 探索范围适应和无情和无动感的症状之间的关系.
主要方法:
- 50名SCZ患者,46名MDD患者和56名对照人完成了基于努力的快乐体验任务.
- 该任务测量了预期值 (EV) 和结果值 (OV) 的调整.
- 分析了适应措施和无情/激励症状之间的相关性.
主要成果:
- 与对照组相比,SCZ和MDD患者表现出改变的适应范围,具有不同的模式.
- SCZ患者表现出过度适应OV和减少适应EV.
- 患有MDD的患者显示OV适应性减弱,但EV适应性完好.
结论:
- 在精神分裂症和严重抑郁症中,适应范围发生显著变化.
- 在SCZ和MDD分别发现了OV和EV适应的具体缺陷.
- 障碍范围适应是一种潜在的神经机制,也是SCZ和MDD中无情感和无动机的治疗标.
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