检查继续和维持精神分裂症电治疗的临床有效性
Rachna George1, Vijay Krishnan1, Daniel Talbot2
1Western Sydney Local Health District, Westmead, NSW 2145, Australia.
Asian journal of psychiatry
|December 29, 2023
概括
持续/维护 电疗法 (C/M-ECT) 在精神分裂症患者中有效保持疾病严重程度长达六个月. 与其他电极位置相比,双腔ECT放置进一步增强了症状维持.
科学领域:
- 精神病学是一种精神病学.
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 急性电疗法 (ECT) 对精神分裂症有效,但关于继续/维持ECT (C/M-ECT) 的数据有限.
- 调查C/M-ECT在精神分裂症中的有效性对于长期治疗策略至关重要.
- 很少有研究在对精神分裂症患者的自然环境中检查了C/M-ECT.
研究的目的:
- 评估C/M-ECT在住院精神分裂症患者的临床有效性.
- 分析C/M-ECT对随时间推移疾病严重性的影响.
- 为了比较只有急性ECT与C/M-ECT的有效性.
主要方法:
- 在悉尼一家公立医院接受C/M-ECT的46名精神分裂症住院患者的回顾性分析.
- 研究了138个治疗周期 (71个仅为急性,67个急性延续/维护).
- 利用线性混合效应模型评估四个时间点临床全球印象-严重性 (CGI-S) 评分的变化.
主要成果:
- 只有急性和急性连续/维护ECT周期都显示了相同的周期前和周期后CGI-S得分和差异得分.
- 持续/维护周期显示CGI-S的初始急剧下降,其次是对数增长,维持满意的得分大约6个月.
- 在维护期间,双 ECT 安置显著影响了 CGI-S 评分,这表明与其他电极安置相比,症状恶化速度较慢.
结论:
- 在急性治疗后至少六个月,C/M-ECT保留了对精神分裂症疾病严重性的治疗效果.
- 与其他电极位置相比,双腔ECT放置与更好的长期维持临床严重性有关.
- 在自然的临床环境中,C/M-ECT是长期治疗精神分裂症的可行选择.
更多相关视频
09:07Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
12.1K
04:29Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
28.6K
相关概念视频
01:30Electroconvulsive Therapy
41
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
41
01:24Mania and Antimanic Drugs: Overview
186
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
186
01:29Psychological and Sociocultural Causes of Schizophrenia
91
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
91
01:30Psychosurgery
56
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
56