药物耐药性症中默认模式网络的结构和功能变化
Jinxin Bu1, Hangxing Yin2, Nanxiao Ren1
1Department of Functional Neurosurgery, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China.
耐药性 (DRE) 涉及改变的默认模式网络 (DMN) 连接. 与额叶 (FLE) 相比,叶 (TLE) 显示左海马和前之间结构和功能连接减少.
科学领域:
- 神经科学是一个神经科学.
- 的研究研究.
- 脑部成像 脑部成像
背景情况:
- 耐药性 (DRE) 在临床管理中提出了重大挑战.
- 默认模式网络 (DMN) 在内在大脑功能中起着至关重要的作用,并与各种神经系统疾病有关.
- 了解叶 (TLE) 和额叶 (FLE) 等DRE亚型的DMN变化对于有针对性的干预至关重要.
研究的目的:
- 调查抗药性中默认模式网络 (DMN) 的大脑网络特性和连接异常.
- 通过概率纤维追踪和功能连接 (FC) 分析,探索TLE和FLE患者的DMN内的结构和功能连接变化.
主要方法:
- 招募了33名DRE患者 (18名TLE,15名FLE) 和30名健康对照 (HC).
- 使用FreeSurfer计算的DMN隔膜大脑区域体积分数.
- 在MATLAB中使用数据处理和脑成像分析 (DPABI) 进行了FC分析,并通过概率纤维追踪进行了结构连接分析.
主要成果:
- 与HC相比,群体表现出较低的左侧前 (PCUN) 体积.
- 与FLE相比,TLE患者在左海马 (HIP) 和PCUN/中间额头之间,以及在右下叶 (IPL) 和右上状之间显示了减少的FC.
- 与HC相比,FLE患者在右IPL和叶之间,以及左上额头 (SFG) 和双边上状之间增加了FCs. 与FLE相比,TLE显示了结构连接的改变,包括左侧SFG-左侧PCUN连接的增加和左侧HIP-左侧后带带状/左侧PCUN连接的减少.
结论:
- 无论是TLE还是FLE患者,都在DMN中表现出结构和功能上的改变.
- 与FLE患者相比,在TLE患者中观察到左HIP和PCUN之间的结构和功能连接强度降低.
- 这些明显的连接性改变可以作为区分TLE和FLE的潜在生物标志物.
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