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Sergio Rosemberg^1,2

¹Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia, São Paulo SP, Brazil.

Arquivos de neuro-psiquiatria

|December 29, 2023

概括

长期相关瘤 (LEATs) 是良性脑瘤,通常会导致难治性. 早期的神经外科手术可能会改善结果,尽管LEAT和之间的确切关系需要进一步研究.

科学领域:

神经瘤学神经瘤学
儿科神经学儿科神经学
发病学 (Epileptology) 是一个专业的学科.

背景情况:

长期相关瘤 (LEATs) 通常是良性的,低度的 (世卫组织第1级) 天体细胞或神经神经元系的瘤.
这些瘤主要影响儿童,青少年和年轻成年人,经常呈现慢性耐药性作为唯一的临床症状.
常见的LEAT包括性质瘤 (GG) 和异胚性神经上皮瘤 (DNT),以及皮洛细胞性星细胞瘤 (PA) 和血管中心质瘤 (AG).

研究的目的:

审查LEATs的临床病理特征和最近的分子分类.
讨论目前对LEAT和之间的关系的理解.
突出早期神经外科干预对LEATs的潜在好处.

主要方法:

审查最近的分子研究和世卫组织2021年脑瘤分类.
对LEATs的临床表现和诊断标准的分析.
综合现有关于神经外科治疗患者神经外科治疗疗效的文献.

主要成果:

最近的分子研究导致了新的LEAT实体的识别,包括具有MIB或MYBL1改变的扩散性星细胞瘤,年轻人多形低度神经上皮瘤 (PLNTY) 和多局部和真空神经元瘤 (MVNT).
在LEAT和之间确切的病理生理联系仍在调查中.
有证据表明,早期手术干预可以对LEAT和耐火性患者的临床结果产生积极影响.

结论:

LEAT涵盖了一系列与慢性相关的良性脑瘤,基于分子发现的分类不断演变.
虽然LEAT患者的病因尚未完全阐明,但外科治疗通常被认为是有益的.
需要进一步的研究来澄清LEAT和的关系,并优化治疗策略.

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