环境空气污染和自发流产率
Amelia K Wesselink1, Kipruto Kirwa2, Perry Hystad3
1Department of Epidemiology, Boston University School of Public Health, USA.
Environmental research
|December 29, 2023
概括
在加拿大,暴露于空气污染,特别是细颗粒物 (PM2.5) 与自发流产 (SAB) 的风险较高有关,但在美国并非如此. 这项研究突出了影响早期怀孕结果的潜在环境因素.
科学领域:
- 环境流行病学环境流行病学
- 生殖健康 生殖健康
- 公共卫生 公共卫生
背景情况:
- 自发流产 (SAB) 影响了很大一部分怀孕,但可修改的风险因素仍然在很大程度上未被确定.
- 环境空气污染是一种潜在的环境暴露,会影响怀孕结果.
- 了解空气污染物和SAB之间的联系对于公共卫生干预至关重要.
研究的目的:
- 调查暴露于环境空气污染和自发流产 (SAB) 发生率之间的关联.
- 研究细颗粒物 (PM2.5),二氧化 (NO2) 和臭氧 (O3) 对SAB速率的影响.
- 为了区分空气污染对美国和加拿大的SAB的潜在影响.
主要方法:
- 利用了来自在线妊娠研究 (PRESTO) 预孕队列研究的数据.
- 分析了从4643名美国和851名加拿大参与者在2013-2019年期间注册的数据.
- 估计的空气污染物度 (PM2.5,NO2,O3) 使用国家时空模型和通过调查问卷评估SAB发病率,使用Cox比例危险回归.
主要成果:
- 在19%的怀孕中,结果是SAB.
- 在加拿大 (HR=1.29),较高的PM2.5度与SAB发病率有中度的积极关联,但在美国 (HR=0.94) 没有.
- 在这两个国家中,NO2或O3暴露与SAB发病率之间没有发现显著的关联.
结论:
- 住宅暴露于环境PM2.5,NO2和O3的证据显示,对影响美国SAB发病率的证据有限.
- 在加拿大观察到PM2.5暴露与SAB发病率之间的中度正相关性.
- 研究结果表明,空气污染对早孕流产的影响存在潜在的地理差异.
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