定义孕妇碳水化合物缺乏转激素的三个月具体参考间隔
Eva-Leonne Göttgens1, Laurens Haverkate2, Marloes Langelaan1
1Result Laboratory for Clinical Chemistry and Hematology, Amphia Hospital, Breda, the Netherlands.
Clinica chimica acta; international journal of clinical chemistry
|December 29, 2023
概括
在怀孕期间,碳水化合物缺乏转激素 (CDT) 水平增加,需要三个月特定的参考间隔. 建立了新的间隔,以避免在怀孕期间的酒精查中出现错误阳性.
科学领域:
- 临床化学 临床化学
- 生物标志物 生物标志物
- 怀孕诊断 怀孕诊断 怀孕诊断
背景情况:
- 怀孕期间过度饮酒对胎儿发育构成风险.
- 缺乏碳水化合物的转激素 (CDT) 是酒精摄入量的生物标志物.
- 怀孕期间CDT水平升高可能与酒精无关,使查复杂化.
研究的目的:
- 为了研究整个怀孕期间CDT水平的变化.
- 为了确定CDT的准确,三季度依赖的参考间隔.
- 为了提高怀孕个体的酒精滥用查准确度.
主要方法:
- 分析了来自147名健康孕妇的439个血清样本,跨越三个月和产后.
- 使用了高性能液态染色学 (HPLC) 和N-Latex免疫细胞测定法.
- 为CDT建立了新的三个月特定的参考间隔.
主要成果:
- 观察到CDT%的季度取决于季度的增加,高达39.4%的CDT超过标准上限.
- 方法特定的%DST/%CDT的上限参考值被确定为每个三个月和产后.
- 惠普LC方法的极限值:1.55% (T1),1.96% (T2),2.05% (T3),1.35% (分娩后). 这是一个很大的问题.
- N-乳糖免疫试验的临界值为2.02% (T1),2.19% (T2),2.19% (T3),1.96% (产后). 乳糖免疫试验的临界值为2.02% (T1),2.19% (T2),2.19% (T3),1.96% (产后). 乳糖免疫试验的临界值为2.02% (T1),2.19% (T2),2.19% (T3),1.96% (产后).
结论:
- 在怀孕期间,CDT水平显著上升,这种上升方式取决于方法.
- 确定的三个月和方法特定的参考间隔至关重要.
- 这些间隔将有助于防止怀孕妇女出现假阳性酒精滥用查结果.
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