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分支链氨基酸代谢缺陷通过激活mTOR信号来促进α细胞的增殖

Yulin Yang1, Shushu Wang1, Chunxiang Sheng1

  • 1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Molecular and cellular endocrinology
|December 29, 2023
PubMed
概括

在胰腺α细胞中缺陷的分支链氨基酸 (BCAA) 分解通过mTOR信号增加了它们的增殖. 这不会影响葡萄糖分泌或整体葡萄糖平衡.

关键词:
分支链α-基酸脱酶E1α子单元分支链氨基酸分支链氨基酸.催化作用的催化作用.葡萄糖的新陈代谢.在mTOROR中使用mTOR.一个α细胞.

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