咖啡因补充剂的人体效应是否取决于CYP1A2基因型? 一个系统的审查与元分析
Jieping Wang1, Luthfia Dewi2, Yundong Peng3
1Laboratory of Exercise Biochemistry, University of Taipei, Tianmu Campus, Taipei 11153, China; Department of Emergency Medicine, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China.
咖啡因可以增强CYP1A2A等位基因类型的运动员的骑自行车表现. 然而,咖啡因并没有改善Wingate或CMJ的表现,无论CYP1A2基因型如何.
科学领域:
- 运动科学 运动科学 运动科学
- 遗传学 是一个遗传学.
- 营养生物化学 营养生物化学
背景情况:
- 咖啡因是一种已知的人体营养助剂,但个人的反应各不相同.
- 遗传变异,特别是人类细胞染色体P450酶1A2 (CYP1A2) 基因 (rs762551) 的遗传变异,可能解释了这些差异.
- 这项研究系统地审查了CYP1A2基因型对咖啡因人体效应的影响.
研究的目的:
- 评估CYP1A2基因变异如何影响运动员在摄入咖啡因后的运动表现.
- 对研究这种关系的现有研究进行元分析.
主要方法:
- 在四个主要数据库中进行了系统的文献搜索,直到2023年3月.
- 固定效应的元分析被用来计算效应大小的加权平均差异 (WMD).
- 根据CYP1A2基因型 (AA与AC/CC) 进行了子组分析.
主要成果:
- 包括12项研究,共666名参与者.
- 咖啡因显著改善了骑自行车计时试验的表现 (WMD = -0.48,p = 0.007).
- 在循环时间试验中,只在具有A基因组 (WMD = -0.90,p = 0.002) 的个体中观察到性能改善,而不是C基因组 (p = 0.53).
- 咖啡因没有显著影响Wingate或反运动跳跃测试 (CMJ) 的表现,无论CYP1A2的基因型.
结论:
- 具有CYP1A2 A等位基因型的运动员在补充咖啡因后表现出更好的骑自行车计时赛表现.
- 与安慰剂相比,急性咖啡因摄入并没有改善Wingate或CMJ的表现,无论CYP1A2的基因型如何.
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