红细胞陷在缺血性急性损伤中的病理生理学
1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Comprehensive Physiology
|December 29, 2023
概括
在急性损伤 (AKI) 后,红细胞在脏中被困,导致严重的管道损伤. 了解和预防这种红细胞积累是改善脏恢复的关键.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 病理生理学 病理生理学
- 微循环是一种微循环.
背景情况:
- 红血细胞 (RBC) 陷,红血细胞在外髓中的积累,是缺血性急性损伤 (AKI) 的标志.
- 虽然与脏恢复相关,但其在AKI病原发生中的作用被低估了.
- 新出现的证据表明,在缺血-再输液后的早期管状损伤中,红细胞被困.
结论:
- 红细胞捕获是缺血性AKI的一个关键因素,可能是可以预防的.
- 进一步调查红细胞捕获机制和相关损伤对于改善AKI结果至关重要.
相关概念视频
Renal Corpuscle
2.3K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.3K
Dialysis
320
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
320
Nephrons
2.5K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.5K
Kidney Structure
69.7K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
69.7K


