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Updated: Jul 6, 2025

Analyzing Large Protein Complexes by Structural Mass Spectrometry
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Published on: June 19, 2010

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解码复杂性在合成的寡核酸:解凝聚异酸不纯离子通过高分辨率质谱学解

A M Abdullah1, Cynthia Sommers1, Jason D Rodriguez1

  • 1Division of Complex Drug Analysis, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, St. Louis, Missouri 63110, United States.

Analytical chemistry
|December 29, 2023
PubMed
概括

本研究引入了一种使用高分辨率质谱的直接方法,用于识别和量化合成寡核酸中的凝结杂质. 该技术利用同位素包裹进行核酸变异的准确分析,改进了杂质分析.

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