肺部康复对血造干细胞移植接受者的影响:一项随机对照研究
Selin Bayram1, Gülşah Barğı2, Zeliha Çelik3
1Department of Physical Therapy and Rehabilitation, Faculty of Health Sciences, Gazi University, 06490, Emek, Ankara, Turkey. selinbayram@gazi.edu.tr.
概括
在血造干细胞移植 (HSCT) 期间,有或没有鼓舞性肌肉训练 (IMT) 的肺康复 (PR) 保持了肺功能和生活质量. 然而,呼气肌的强度和运动能力在两组中都下降.
科学领域:
- 血液学 血液学 血液学
- 肺部病理学 肺部病理学
- 康复医学 康复医学 康复医学
背景情况:
- 造血干细胞移植 (HSCT) 经常导致运动能力和生活质量 (QOL) 的下降.
- 在HSCT期间建议进行运动训练,以保持心肺呼吸能力.
- 关于肺部康复 (PR) 对HSCT接受者的影响的研究有限.
研究的目的:
- 调查两种不同的PR计划对HSCT患者最大运动能力,呼吸肌功能,肺功能和QOL的影响.
- 为了比较单独的PR与与鼓舞性肌肉训练 (IMT) 结合的PR的疗效.
主要方法:
- 一项前性,随机的,受控的,三盲研究,涉及30名住院的HSCT患者.
- 患者被分配到PR组或PR加IMT组.
- 干预措施包括有氧运动训练,抵抗运动训练和IMT. 测量结果:最大的运动能力,呼吸肌肉强度和耐力,肺功能和QOL.
主要成果:
- 肺功能,呼吸肌肉强度和耐力以及QOL在组内没有显著变化.
- 两组都经历了呼吸肌肉强度 (MEP),氧气消耗峰值和氧气脉冲的显著下降.
- PR + IMT 组在呼吸储备和限制方面表现出改善,呼吸时间保持在几分钟内,呼吸障碍减少.
结论:
- 有或没有IMT的PR可以保持肺功能,呼吸肌肉的强度和耐力,以及在HSCT后的QOL.
- 尽管进行了PR干预,呼吸道肌肉强度和最大运动能力却有所下降.
- 在HSCT期间,PR应根据个体患者的临床和血液状况进行量身定制.
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