静脉血栓塞栓症在探索类人类太空飞行中的探索类
Aerospace medicine and human performance
|December 29, 2023
概括
太空飞行带来了静脉血栓栓塞 (VTE) 的风险,原因是血液动力学和凝固的改变. 宇航员,特别是使用口服避孕药的女性,面临着增加的VTE风险,需要改进诊断和对策.
科学领域:
- 太空医学 太空医学
- 生理学 生理学 生理学
- 血液学 血液学 血液学
背景情况:
- 在太空飞行期间发现的深静脉血栓症需要了解静脉血栓栓塞 (VTE) 的风险.
- 目前对太空飞行中VTE机制,风险和对策的知识需要综合.
研究的目的:
- 在太空飞行背景下审查和综合有关静脉血栓塞栓症 (VTE) 的现有证据.
主要方法:
- 进行了从创立到2023年4月的文献审查.
- 在PubMed中搜索了关于太空飞行/无重量和静脉血栓/栓塞的人类研究.
- 不包括细胞和动物模型.
主要成果:
- 确定了63篇相关论文,包括原始研究和评论.
- 关键发现包括改变静脉血动力学,增加凝血标志物 (纤维素),低蛋白血症和免疫功能障碍.
- 妇女使用口服避孕药是额外的危险因素.
结论:
- 空间中的液体移动会导致静脉静止,内皮损伤和凝血激活.
- 由于生理因素和口服避孕药,女性宇航员面临复杂的静脉瘤风险.
- 未来的努力应集中在增强诊断成像 (例如,载体流成像) 和生物标志物 (例如,白蛋白,p-selectin) 上.
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