以往脑震荡严重程度与大脑微观结构的关联,使用平均明显传播器磁共振成像
Bryna D Goeckner1, Benjamin L Brett2,3, Andrew R Mayer4,5,6
1Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Human brain mapping
|December 30, 2023
概括
平均明显传播器 (MAP) MRI显示运动员在脑震荡后出现慢性微观结构变化. 更严重的脑震荡,特别是失去意识 (LOC),显示出更大的白质损伤.
科学领域:
- 神经成像是一种神经成像.
- 运动医学 运动医学
- 神经学 神经学
背景情况:
- 在运动员中使用MRI扩散研究后观察到慢性微观结构组织异常,但研究结果不一致.
- 涉及创伤后记忆丧失 (PTA) 和/或意识丧失 (LOC) 的脑震荡与更严重的生理损伤有关.
- 与传统的扩散张力成像相比,平均明显传播器 (MAP) MRI 对组织损伤具有更高的灵敏度.
研究的目的:
- 通过使用先进的MAP-MRI技术,研究先前脑震荡严重程度对大脑微观结构的影响.
- 为了比较有或没有脑震荡史的运动员之间的微观结构指标,并根据脑震荡严重程度 (PTA/LOC) 进一步分层.
主要方法:
- 111名大学运动员 (38名女性) 接受半结构面试,详细了解脑震荡史,包括PTA和LOC.
- 计算了MAP-MRI指标 (平均非高斯扩散 [NG 平均],返回原点概率 [RTOP],平均平方位移 [MSD]).
- 贝叶斯多层次建模分析了脑震荡史/严重程度和MAP-MRI指标在白质和皮层下灰质感兴趣区域 (ROI) 之间的关联.
主要成果:
- 在灰质中,先前的脑震荡与白体中NG平均值和RTOP的降低以及骨中NG平均值的降低有关.
- 白物质显示,所有模型中的所有ROI均降低了NG平均值,与LOC相关的进一步降低.
- 以前的脑震荡与LOC具体相关于白质ROI的RTOP降低和MSD增加. 在探索性分析中注意到基于性别的差异.
结论:
- 灰质中的微观结构变化与脑震荡的一般史有关.
- 白质完整性显示了严重程度与先前脑震荡的相关性,特别明显的是LOC.
- MAP-MRI是一种敏感的工具,用于检测运动员脑震荡后的慢性微观结构变化,这对了解受伤严重程度有意义.
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