绝经后妇女的维生素D和维生素K状况正常和低骨矿物质密度
Sieglinde Zelzer1, Andreas Meinitzer1, Dietmar Enko1
1Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Clinical chemistry and laboratory medicine
|December 30, 2023
概括
维生素D和维生素K水平似乎不会影响绝经后妇女的骨矿物质密度或质量. 该研究没有发现维生素状况和骨健康之间的联系,除了维生素D代谢产物和副甲状腺激素之间的反向关系.
科学领域:
- 营养生物化学 营养生物化学
- 骨的新陈代谢 骨的新陈代谢
- 内分泌学 在内分泌学.
背景情况:
- 维生素D和维生素K在骨健康中的作用受到争论.
- 关于它们对骨矿物质密度 (BMD) 的影响的现有证据存在争议.
- 绝经后的女性是骨健康研究的关键人口统计,原因是骨质疏松症风险增加.
研究的目的:
- 在绝经后的妇女中量化关键维生素D和K代谢物的血清度.
- 研究这些维生素代谢物与骨矿物质密度 (BMD) 和骨质量之间的关系.
- 探索维生素D和维生素K对骨健康标志物的潜在协同作用.
主要方法:
- 血清代谢物的LC-MS/MS分析:25-基维生素D (25[OH]D),24,25-二基维生素D (24,25(OH) 2D),基 (K1),梅纳基-4 (MK-4),以及MK-7.
- 计算维生素D代谢物比率 (VMR).
- 通过双X射线吸收计测量骨周转标记物 (PTH,PINP,CTX-I) 和 BMD.
主要成果:
- 在正常和低BMD的女性之间没有观察到维生素代谢物水平的显著差异.
- 骨矿物质密度和椎骨分数在充足和不足的维生素状态组中是可比的.
- 在维生素D代谢物 (25[OH]D,24,25(OH) 2D,VMR) 和副甲状腺激素 (PTH) 之间发现了反向相关性,但不是骨周转标记物PINP或CTX-I.
结论:
- 维生素D和维生素K的状况与这一绝经后妇女队列的骨矿物质密度或椎骨质量无关.
- 主要观察到的关联是维生素D代谢物和PTH水平之间的反向关系.
- 没有发现维生素D和维生素K对骨健康参数的协同作用.
相关概念视频
01:25Role of Vitamins in Maintaining Bone Health
3.3K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.3K
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:21Skeleton and Calcium Homeostasis
4.5K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.5K
01:40Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
01:31Essential Minerals for Bone Health
4.0K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.0K
01:17Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K