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患有多囊性功能的儿童的结果:是否涉及副作用?

Sevgi Yavuz¹, Aysel Kıyak¹, Serdar Sander²

¹Division of Pediatric Nephrology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.

Birth defects research

|December 30, 2023

概括

患有多囊性形 (MCDK) 的儿童面临衰退的风险. 高血压是这些患者慢性病 (CKD) 进展的关键因素.

科学领域:

儿科脏病学儿科脏病学
泌尿器科泌尿器科泌尿器科泌尿器科
医疗成像医学成像

背景情况:

多囊性功能 (MCDK) 是一种常见的先天性异常.
产前超声波经常检测到MCDK,需要进一步评估受影响的儿童.

研究的目的:

描述诊断为MCDK的儿童的临床特征.
为了确定MCDK的横向性是否会影响患者的治疗结果.

主要方法:

分析了39名MCDK患者和20名对照组的队列.
评估了患者的eGFR值,并对MCDK患者和对照组进行了比较,以及右侧和左侧MCDK病例.

主要成果:

在右 (51.3%) 和左 (48.7%) 两侧,MCDK均分布.
重要发现包括逆侧扩大 (82%),内置 (48.7%) 和并发症,如尿路感染 (35.8%),微专 (30%),高血压 (12.8%) 和慢性病进展 (17.9%).
高血压成为慢性病的独立风险因素,与对照组相比,患者的EGFR降低,cystatin C增加和microalbuminuria增加. 右侧的MCDK显示了更高的cystatin C水平.

结论:

MCDK使儿童易患脏恶化,即使最初是正常的EGFR.
虽然右侧MCDK显示了较高的cystatin C水平,但侧向性并没有显著影响整体结局.
高血压被确定为MCDK儿童中CKD进展的主要决定因素.

关键词:

受影响的侧面.氨酸C 氨酸C 氨酸这种高血压,高血压.多囊性失塑性脏多囊性失塑性脏预后预后预后

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