暴露于产前感染和儿童内化和外化问题的发展:基于人口的纵向研究
Anna Suleri1,2, Anna-Sophie Rommel3, Alexander Neumann1,2
1Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
怀孕期间常见的感染与儿童持续的精神症状有关,从幼儿期持续到青春期. 即使考虑到遗传和环境因素,也观察到这种关联.
科学领域:
- 围产期健康 围产期健康
- 儿童精神病学 儿童精神病学
- 流行病学 流行病学
背景情况:
- 产前感染暴露与后代的精神病风险有关.
- 以前的研究集中在严重的感染和单一的时间点上,经常忽视混因素.
- 这项研究检查了常见的产前感染和重复的精神病症状评估.
研究的目的:
- 调查常见的产前感染与儿童精神症状之间的潜在关联.
- 为了评估症状持续性和时间效应在不同的三个月.
- 为了控制遗传和环境的混因素.
主要方法:
- 利用了一个潜在的怀孕队列 (R世代; n=3,598).
- 开发了每个三个月的产前感染得分.
- 通过使用线性混合效应模型分析重复的儿童精神症状数据 (年龄为1.5-14岁),并对混因素进行调整.
主要成果:
- 产前感染与更高的总体,内化和外化儿童精神问题有关.
- 这些影响随着时间的推移,从幼儿时期到青春期持续存在.
- 没有发现显著的三个月特异性影响或与儿童性行为的相互作用.
结论:
- 常见的产前感染可能是持续的儿童精神症状的危险因素.
- 关联很早就存在,并持续到青春期.
- 需要进一步研究因果推理设计,以证实因果关系,因为潜在的未测量混.
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