多环芳和牙周炎之间的关联:来自大型基于人群的研究结果
Yuxuan Wu1, Han Yang1, Weiqiu Jin2
1Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Journal of clinical periodontology
|December 30, 2023
概括
通过尿路代谢物测量的多环芳 (PAHs) 的暴露与牙周炎有关. 这项研究强调了预防牙疾病的环境因素.
科学领域:
- 环境健康 环境健康
- 口腔健康 口腔健康
- 毒理学 毒理学 毒理学
背景情况:
- 牙周炎是一种普遍存在的口腔炎症状况.
- 多环芳 (PAH) 是常见的环境污染物.
- 尿中的代谢物作为PAH暴露的生物标志物.
研究的目的:
- 调查尿中PAH代谢物与牙周炎之间的关联.
- 分析多种PAH代谢物的独立和联合作用.
主要方法:
- 利用了来自国家健康和营养检查调查 (2009-2014) 的数据.
- 采用加权二进制物流回归,贝叶斯核机器回归 (BKMR) 和加权量子量和 (WQS) 回归.
- 分析了六种PAHs (OH-PAHs) 的尿中单氧化代谢产物.
主要成果:
- 包括3413名参与者;在牙周炎组中发现了更高的OH-PAH水平 (p < .001).
- 在单个OH-PAH和牙周炎之间观察到积极的关联 (p < .05).
- OH-PAH与增加的附着损失,牙周口袋深度和牙损失相关.
结论:
- 和它们的混合物与牙周炎有积极的关联.
- 研究结果提供了通过管理环境暴露来预防牙周炎的见解.
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