[患有血液性恶性瘤和并发性慢性肝炎C的患者的预后因素]
M S Nozhkin1, D A Lioznov1,2, T V Antonova1
1Pavlov First Saint Petersburg State Medical University.
Terapevticheskii arkhiv
|December 30, 2023
概括
肝炎C病毒 (HCV) 感染会影响患有血液癌症的患者的治疗结果. 高龄,延迟的抗病毒治疗和营养不良预测了这些患者的死亡率.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 型肝炎病毒 (HCV) 感染是一个全球性的健康问题.
- 患有血液性恶性瘤的患者可能同时患有HCV感染.
- 肝炎病毒对血性恶性瘤的预后的影响需要进一步研究.
研究的目的:
- 评估HCV感染对被诊断为血液性恶性瘤的患者预后的影响.
- 为了确定HCV感染患者与血液恶性瘤死亡率的预测因素.
主要方法:
- 研究了96名患有抗HCV抗体和血液恶性瘤的患者队列.
- 患者数据包括人口统计,恶性瘤类型,HCV诊断时间,肝纤维化评估 (METAVIR) 和治疗史.
- 用回归分析来确定死亡的预测因素.
主要成果:
- 慢性型肝炎 (CHC) 在恶性瘤诊断之前,期间或之后分别在46.9%,38.5%和14.6%的患者中被诊断出.
- 在40%的患者中观察到显著的肝纤维化 (F3-4);只有20.8%接受过先前的抗病毒治疗.
- 55岁以上的年龄,晚期抗病毒治疗和营养状况不佳是死亡率的重要预测因素.
结论:
- 在患有血液性恶性瘤的患者中,HCV感染是一个复杂的挑战.
- 及时的抗病毒治疗和营养支持对于改善结果至关重要.
- 需要采取教育举措,以解决医疗保健专业人员在血液瘤学中关于HCV的知识差距.
更多相关视频
12:24A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.2K
00:06An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
8.9K
相关概念视频
Role of Hematopoietic Growth Factors
1.4K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
1.4K
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
