[局部组合治疗在急性外耳炎患者中的有效性和安全性]
A V Gurov1,2, A I Kriukov1,2, G B Shadrin1
1Sverzhevsky Research Clinical Institute of Otorhinolaryngology.
Terapevticheskii arkhiv
|December 30, 2023
概括
这项研究分析了急性外耳炎的微生物特征,并发现联合药物Candibiotic在经验治疗中非常有效和安全. 康迪生菌在急性外耳炎患者中显示出显著的临床分离和微生物根除.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 外耳炎 (AOE) 是外耳道的常见炎症状况.
- 了解AOE的微生物环境对于有效治疗至关重要.
- 经验疗法旨在在最终识别之前涵盖最可能的病原体.
研究的目的:
- 在被诊断患有急性外耳炎的患者中描述微生物菌群.
- 评估固定组合局部药物的临床疗效和安全性 (氨基醇,克洛特利马,贝克洛美沙,利多卡因) 作为AOE的经验性治疗.
主要方法:
- 从963名患有AOE症状的患者 (2017-2022) 的门诊病例记录的回顾性分析.
- 专注于用Candibiotic联合药物治疗的患者.
- 评估临床和微生物学结果,以及安全数据.
主要成果:
- 细菌植物占主导地位 (60.6%),其次是细菌-真菌协会 (26%) 和真菌植物 (11.6%).
- 常见的分离病原体包括Pseudomonas spp.,Staphylococcus spp.,Candida spp.和Aspergillus spp. 这些病原体都被发现.
- 在71.0%的患者中,使用甘草生菌导致69.7%和87%的微生物根除在7天内症状消失,不良事件率低 (0.04%).
结论:
- 联合药物Candibiotic显示出高临床疗效和有利的安全性概况,用于经验性治疗急性外耳炎.
- 康迪生菌是一种适合的选择,用于初始的经验性治疗患者呈现与AOE.
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