SARS-CoV-2诱导的血管内皮功能障碍:直接或间接的影响?
Kathy O Lui1, Zhangjing Ma1, Stefanie Dimmeler2
1Department of Chemical Pathology, and Li Ka Shing Institute of Health Science, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Sha Tin, New Territories, 999077 Hong Kong, China.
Cardiovascular research
|December 30, 2023
概括
COVID-19和长期COVID患者表现出内皮功能障碍,但原因 - - 直接感染或炎症 - - 仍在争论中. 本综述探讨了SARS-CoV-2引起的血管问题中的ACE2表达和替代机制.
科学领域:
- 心血管生物学 心血管生物学
- 传染性疾病 传染性疾病
- 细胞生物学 细胞生物学
背景情况:
- 内皮功能障碍在COVID-19和长期COVID中很普遍.
- 直接的SARS-CoV-2感染与系统性炎症在内皮损伤中的作用尚不清楚.
- SARS-CoV-2 进入受体 ACE2 的表达因血管细胞而异.
研究的目的:
- 对COVID-19中内皮ACE2表达的当前研究进行审查.
- 探索SARS-CoV-2引起的内皮功能障碍的ACE2-依赖和独立机制.
- 讨论COVID-19相关心血管并发症的临床表现和治疗策略.
主要方法:
- 关于内皮细胞ACE2表达的最近研究的文献综述.
- 分析SARS-CoV-2与不同血管细胞类型的相互作用.
- 讨论有助于内皮细胞激活的替代途径.
主要成果:
- 内皮细胞 (ECs) 在对SARS-CoV-2的反应中表现出异质的ACE2表达.
- 在EC中直接复制SARS-CoV-2的证据有限.
- 独立于ACE2的机制有助于内皮细胞激活.
结论:
- 要了解SARS-CoV-2对内皮的影响,需要考虑ACE2-依赖和独立的途径.
- 针对血管功能障碍机制可能会改善COVID-19心血管并发症的治疗方法.
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