肥胖和白血病:生物机制,前景和挑战
Dimitrios Tsilingiris1, Natalia G Vallianou2, Nikolaos Spyrou3
1First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece.
Current obesity reports
|December 30, 2023
概括
肥胖会增加白血病的风险和恶化结果,特别是在儿童急性淋巴细胞白血病 (ALL) 幸存者中. 通过饮食,运动和医疗干预来控制体重可以帮助预防和管理白血病.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 肥胖是一个重要的风险因素,涉及到许多癌症的发展,包括白血病.
- 白血病是最常见的儿童癌症,约占所有新发癌症病例的2.5%和癌症死亡率的3.1%.
- 儿童急性淋巴细胞白血病 (ALL) 幸存者特别容易患肥胖相关并发症.
研究的目的:
- 审查关于肥胖和白血病的流行病学数据.
- 为了评估肥胖对儿童白血病结果的影响,所有幸存者.
- 探索肥胖与白血病相关的机制,并讨论管理策略.
主要方法:
- 综述流行病学数据和关于肥胖和白血病的现有文献.
- 对研究肥胖对白血病风险和结果的影响的研究分析.
- 检查病理生理路径和潜在的治疗干预措施.
主要成果:
- 肥胖与白血病风险增加和患者的治疗结果较差有关,包括儿童ALL幸存者的复发和死亡率较高.
- 关键的病理生理联系包括骨髓脂肪组织的改变,荷尔蒙失衡 (胰岛素,IGF),炎症 (IL-6,TNF-α),脂肪基因 (莱普,阿迪波内克丁) 和氧化应激.
- 体重增加在童年时常见,所有幸存者,进一步增加复发和死亡风险.
结论:
- 肥胖是白血病的可修改风险因素,强调通过改变生活方式和医疗干预来控制体重的重要性.
- 预防措施,如饮食,运动和药物治疗,以及减肥手术,显示出白血病预防的希望.
- 重用药物和向与肥胖和胰岛素抵抗相关的瘤性途径是潜在的治疗途径.
关键词:
艾迪波基因 (Adipokine) 是一种可怕的药物.肥胖症是一种脂肪.体重指数 (Body Mass Index) 是一个指数.儿童白血病 在儿童白血病.流行病学 流行病学在白血病中,白血病.肥胖问题 肥胖问题更多相关视频
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