维索曼特对骨质母细胞功能和骨发育的直接影响
E Vitali1, A Grasso1, M L Schiavone2
1Laboratory of Cellular and Molecular Endocrinology, IRCCS Humanitas Research Hospital, Rozzano, MI, Italy.
Journal of endocrinological investigation
|December 30, 2023
概括
佩格维索曼特 (PEG) 不影响骨质母细胞功能或骨发育. 这种生长激素受体抗剂可能不会影响壮病患者的骨健康.
科学领域:
- 内分泌学 在内分泌学.
- 骨生物学 骨生物学 骨生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 巨症是由多余的生长激素 (GH) 和类似胰岛素的生长因子I (IGF-I) 引起的,导致骨异常.
- 佩格维索曼特 (PEG) 是一种GH受体对抗剂,通过使IGF-I水平正常化,用于治疗巨病.
- 壮症治疗对骨健康的潜在直接影响需要调查.
研究的目的:
- 研究Pegvisomant (PEG) 对骨质细胞功能 (增殖,分化,矿化) 的影响.
- 评估PEG对斑马鱼模型骨发育的影响.
- 为了确定PEG是否影响GH介导的对骨质母细胞的影响.
主要方法:
- 在体外研究中使用暴露于PEG.的骨质细胞系 (MC3T3-E1,hFOB 1.19) 进行了体外研究.
- 评估细胞增殖,细胞亡,性酸酶活性和矿化.
- 对骨质母细胞分化标记物的基因表达分析 (Alp,Runx2,Opg).
- 使用斑马鱼幼虫进行体内研究以评估骨发育.
主要成果:
- 在实验室中,PEG没有影响骨质细胞的增殖,分化或矿化.
- 在斑马鱼幼虫中,PEG没有改变骨发育.
- PEG抑制了GH诱导的骨质细胞亡和STAT3酸化的减少.
- GH和PEG没有影响IGF-I相关基因表达在骨质细胞中.
结论:
- 这项研究是第一个证明PEG对骨质细胞功能和骨发育缺乏直接影响的研究.
- 研究结果表明,PEG可能不会对壮病患者的骨健康产生不利影响.
- 结果对在接受PEG治疗的壮病患者的骨健康管理有影响.
相关概念视频
Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Role of Vitamins in Maintaining Bone Health
3.3K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.3K


