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Updated: Jul 6, 2025

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

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对皮塔瓦斯塔丁与SLCO1B1遗传多态性相关的生理学基础的药理动力学 (PBPK) 建模

Chang-Keun Cho1, Ju Yeon Mo1, Eunvin Ko1

  • 1School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Archives of pharmacal research
|December 30, 2023
PubMed
概括

这项研究开发了一种基于生理学的药理动力学 (PBPK) 模型,以根据SLCO1B1遗传变异预测皮塔瓦斯塔丁药物水平. 该模型准确地预测了皮塔瓦斯塔丁的药理动力学,有助于针对高胆固醇血症的个性化剂量策略.

关键词:
遗传的多态化 遗传多态化这是一个OATP1B1B1的OATP.基于生理学的药理动力学 (PBPK) 模型.皮塔瓦斯塔丁是一种药物.在SLCO1B1B1中,

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