风湿性关节炎患者肝纤维化的相关因素 接受甲醇酸治疗的患者
Maroua Slouma1,1,2, Wided Lahmar3,4, Ghanem Mohamed4,5
1Department of Rheumatology, Military Hospital, 1008, Tunis, Tunisia. maroua.slouma@gmail.com.
Clinical rheumatology
|December 30, 2023
概括
风湿性关节炎患者累积超过3克的甲状腺素面临肝纤维化风险增加. 高龄,代谢综合征,低albuminemia和性酸酶的升高也与纤维化相关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 类风湿病学 类风湿病学
- 临床医学 临床医学
背景情况:
- 关于累积甲状腺素剂量与肝纤维化之间的关联,存在相互矛盾的数据.
- 风湿性关节炎 (RA) 患者接受甲状腺素治疗,有肝脏并发症的风险.
- 识别与甲状腺素诱导的肝纤维化相关的因素对于患者管理至关重要.
研究的目的:
- 为了确定在接受甲铁酸治疗的RA患者中肝纤维化的频率.
- 在这个队列中确定与肝纤维化相关的临床和生化因素.
主要方法:
- 进行了一项涉及RA患者的横截面研究,该研究涉及使用甲醇治疗的RA患者.
- 使用FibroScan评估肝硬度,纤维化通过kPa值来定义.
- 人口,临床和实验室数据以及代谢综合征的流行情况都被收集和分析.
主要成果:
- 68名患者中有9人 (13.2%) 呈现肝纤维化,其中4人 (5.9%) 呈现显著纤维化.
- 与肝纤维化独立相关的因素包括年龄≥60岁,累积甲状腺素剂量≥3g,代谢综合征,性酸酶升高和低albuminemia.
- 这些因素的赔率比率从22.7到59.3不等,p值<0.035.
结论:
- 在RA患者中,累计甲状腺素剂量超过3g与肝纤维化显著相关.
- 代谢综合征,年龄较大,低albuminemia和性酸酶升高是肝纤维化的独立危险因素.
- 建议在接受甲铁酸治疗的RA患者中对肝纤维化进行监测,特别是那些具有危险因素的患者.
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