肺循环系统的特征与未来的肺癌风险有关
Jiantao Pu1,2,3, Andriy Bandos4, Tong Yu1
1Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Medical physics
|December 30, 2023
概括
肺循环系统 (PCS) 形态,特别是肺内静脉体积,预测肺癌风险. 结合PCS特征可以改善肺癌查,并识别高风险个体.
科学领域:
- 放射学和成像科学 放射学和成像科学
- 在瘤学瘤学.
- 心血管科学 心血管科学
背景情况:
- 用低剂量计算机断层扫描 (LDCT) 进行肺癌查,可以识别出许多不会患上这种疾病的人.
- 需要新的生物标志物来提高肺癌查计划的效率,并识别有风险的个体.
研究的目的:
- 调查肺循环系统 (PCS) 形态与肺癌发展之间的关联.
- 在LDCT查扫描中评估PCS特征的预后价值.
主要方法:
- 对PLuSS队列的分析 (3635名肺部查患者,2002-2016).
- 从LDCT扫描中对循环结构的细分和量化.
- 使用危险比率 (HR) 和五倍交叉验证来评估预后能力.
主要成果:
- 肺内静脉体积显示了与未来的肺癌的最强相关性 (HR = 0.63,p < 0.001).
- 包括肺内静脉体积,年龄,吸烟状况和肺气的联合模型显示出强大的预后能力 (HR = 2.20,AUC = 0.74).
- 添加PCS结构改善了风险分层,确定了一个高风险组 (前10%),在15年内患肺癌的风险为28%.
结论:
- PCS特征,特别是肺内静脉体积,是肺癌发展的重要预测因素.
- 这些成像生物标志物增强了超越人口和非循环因素的预后,特别是对于长期风险.
- 大约10%的查人员可以被确定为患肺癌的几倍平均风险.
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