纯粹的通用焦虑障碍 (GAD) 和并发性GAD和抑郁症状背后的共享和独特的失联模式
Haohao Yan1, Yiding Han1, Xiaoxiao Shan1
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Journal of psychiatric research
|December 30, 2023
概括
通用焦虑症 (GAD) 和伴随抑郁症的GAD显示出不同的大脑连接模式. 基线上的异常连接性预测了治疗反应,这表明了GAD潜在的预后生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 通用焦虑障碍 (GAD) 和伴随抑郁症状的GAD代表着不同的临床实体.
- 这些条件之间的休息状态功能连接差异及其作为预后生物标志物的潜力尚未得到充分理解.
- 治疗对这些连接模式的影响需要进一步研究.
研究的目的:
- 为了直接比较纯粹的GAD与并发性GAD和抑郁症的静止状态连接特征.
- 调查这些特征是否可以作为治疗反应的预后生物标志物.
- 为了检查帕洛克治疗后连接性的变化.
主要方法:
- 在使用休息状态fMRI的GAD (G1),并发性GAD和抑郁症 (G2) 和健康对照组 (HCs) 的患者中比较中心度 (DC).
- 使用支持向量回归 (SVR) 来根据基线DC预测治疗反应.
- 在帕洛治疗4周后评估DC的变化.
主要成果:
- 与HC相比,G1和G2都显示左侧中皮质和IV/V皮质的DC减少.
- G1在左侧中间状回环中表现出较低的DC,而G2在右侧下状/状回环中表现出较高的DC.
- 异常基线DC成功预测了治疗反应,超过了全脑DC预测.
- G2响应者在治疗后显示了改变的DC,而G1响应者没有显示显著的变化.
结论:
- 与抑郁症相关的GAD和并发性GAD表现出共同的和独特的大脑失联模式.
- 基线异常连接性作为GAD治疗反应的潜在预后生物标志物.
- 在GAD患者中,休息状态连接性可以通过治疗来调节.
相关概念视频
01:30Generalized Anxiety Disorder
135
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
135
01:18Anxiety: Overview
274
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
274
01:27Panic Disorder
114
Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
114
01:27Depressive Disorders: MDD and Dysthymia
136
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
136
01:28Social Anxiety Disorder
34
Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
34
03:34Theory of Romantic Attachment in Adulthood
43.5K
Attachment is a long-standing connection or bond with others. While Attachment Theory was conceived in developmental psychology to describe infant-caregiver bonding, it's been extended into adulthood to include romantic relationships.
43.5K