探索乳酸素作为疾病病理学和ferroptosis调节的新标志物在妊娠糖尿病中
Sundhar Mohandas1, Kunnath Lakshmanan Milan1, Murugesan Anuradha2
1Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nadu, India.
Journal of reproductive immunology
|December 30, 2023
概括
孕期糖尿病 (GDM) 的妇女的乳酸水平较低,与高血糖和铁死相关. 较低的乳酸可以预测GDM,为早期检测和管理这种情况提供潜在的生物标志物.
科学领域:
- 生殖生物学 生殖生物学
- 代谢障碍 代谢障碍 代谢障碍
- 细胞病理学 细胞病理学
背景情况:
- 铁过载与铁亡有关,这是一种涉及糖尿病的细胞死亡途径.
- 孕期糖尿病 (GDM) 在怀孕期间涉及复杂的代谢和细胞变化.
- 了解GDM阶段的生物标志物对于及时干预至关重要.
研究的目的:
- 评价乳托费林作为GDM不同阶段的预测标记物.
- 为了研究乳酸铁素,GDM病理和铁.
- 探索乳酸在调节高血糖和GDM中的铁化中的作用.
主要方法:
- 在72名孕妇 (NGDM,eGDM,GDM) 的观察研究.
- 测量血清费里,可溶性转激素受体 (sTFR) 和乳酸.
- 在PBMC中对铁灭调节器 (SLC7A11,GPX4) 基因表达的分析.
- 接收器运行特征 (ROC) 曲线分析对于乳二的预测效用.
主要成果:
- GDM患者表现出铁过载和铁平衡中断 (费里升高,sTFR:费里比率降低).
- 与NGDM和eGDM组相比,在GDM中观察到显著较低的乳酸水平.
- 降低的乳二与增加的高血糖和降低GDM患者的ferroptosis调节者的表达相关.
- 经过ROC分析,发现了乳酸作为生物标志物的潜力,可以将GDM与eGDM区分开来.
结论:
- 在已建立的GDM中,乳酪蛋白水平显著降低,这表明乳酪蛋白在疾病进展中的作用.
- 乳酸显示出作为一种有价值的生物标志物用于GDM检测和区分疾病阶段的潜力.
- 这些发现强调了乳二参与调节高血糖和GDM中的铁亡.
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