一个经过实验验证的化启动模型,用于弹驱动的自动注射器
Tyler R Kennelly1, Javad Eshraghi2, Sadegh Dabiri1
1School of Mechanical Engineering, Purdue University, West Lafayette, IN 47906, United States.
International journal of pharmaceutics
|December 30, 2023
概括
弹驱动的自动注射器 (AIs) 中的洞穴是由于注射器的快速加速引起的. 设计因素,如弹力和空气间隙大小,显著影响化严重程度,影响设备和药物完整性.
科学领域:
- 生物医学工程 生物医学工程
- 流体动力学 流体动力学
- 材料科学 材料科学 材料科学
背景情况:
- 洞化,蒸汽泡的形成和崩,是弹驱动自动注射器 (AIs) 的一个关键问题.
- 这种现象是由激活过程中注射器突然加速引起的,导致压力波动和对设备和药物配方的潜在损伤.
研究的目的:
- 调查关键设计参数对弹自动注射器中化开始和严重性的影响.
- 开发一种预测模型,用于分析各种操作条件下的化动态.
主要方法:
- 为弹驱动的自动注射器开发和利用动态模型来模拟组件运动和压力波传播.
- 系统地研究不同空气间隙高度 (1-4毫米),驱动弹力 (8-30N) 和流体粘度 (1-18cP).
- 基于操作参数和预测AI动态的空腔开始和严重程度的分析.
主要成果:
- 自动注射器的动态,洞穴开始和严重程度在很大程度上取决于驱动弹力和空气隙高度.
- 增加弹力和降低空隙高度导致更高的注射器最大加速度和空隙压力.
- 观测到最大的化气泡半径和崩率是由于弹力较高,空气间隙较小,粘度较低.
结论:
- 建立了自动注射器的化标准,证明了与注射器峰值加速的直接相关性.
- 优化设计参数,如弹力和空气间隙大小,对于减轻自动注射器中空洞化至关重要.
- 了解这些因素对于确保弹自动注射器可靠的性能和药物完整性至关重要.
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