在针对多囊卵巢综合征的多电解质多层囊中同时封装和释放apigenin和ascorbic acid
Sangamithra Nehru1, Ajay Guru2, Raman Pachaiappan3
1Department of Physics and Nanotechnology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur 603203, Chengalpattu District, Tamil Nadu, India.
International journal of pharmaceutics
|December 30, 2023
概括
这项研究开发了含有阿比基宁和亚斯科布酸的双药微囊,用于治疗多囊性卵巢综合征 (PCOS). 在PCOS模型中,微囊有效降低了氧化应激,并改善了卵巢功能.
科学领域:
- 生物材料科学 生物材料科学
- 内分泌学 在内分泌学.
- 再生医学是一种再生医学.
背景情况:
- 多囊卵巢综合征 (PCOS) 是女性常见的内分泌疾病,其特征是荷尔蒙失衡和氧化应激.
- 目前的PCOS治疗方法往往存在局限性,这凸显了需要新的治疗策略的需要.
研究的目的:
- 为了研究阿皮基宁 (AP) 和酸 (AC) 在聚 (艾利胺化物) /德克斯硫酸 (PAH / DS) 空心微囊中共同封装的再生潜力,用于PCOS治疗.
- 评估这种双药物输送系统在减少氧化应激和改善卵巢功能方面的有效性.
主要方法:
- 使用层层 (LbL) 组件 (尺寸为4 ± 0.5μm) 制造PAH/DS空心微囊.
- 在微囊内对AP和AC的联合封装和释放研究,通过共聚焦激光扫描显微镜 (CLSM) 证实.
- 在体外评估使用治疗的CHO细胞来评估活性氧物种 (ROS) 水平和亡.
- 使用斑马鱼模型进行体内研究,以评估生物分布,水平和卵巢卵泡发育.
主要成果:
- 在生理条件下,PAH/DS微囊中的高封装效率和AP和AC的成功释放.
- 在体外:双重药物装载的微囊显著降低了受治疗的细胞中的细胞内ROS和亡.
- 在体内:微囊显示有针对性的卵巢生物分布,通过激素清理降低了丸激素水平,并促进了斑马鱼的卵巢卵泡发育.
结论:
- 开发的双药装载PAH/DS微囊有效地为PCOS治疗提供天然化合物 (apigenin和ascorbic acid).
- 该系统在减轻PCOS相关的细胞损伤和通过减少氧化应激和改善卵泡发育来正常化卵巢功能方面显示出显著的潜力.
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