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在发育过程中超重会调节细胞代谢和控制前额叶皮质食物摄入的关键基因
Severina Cassia de Andrade Silva1, Maria Daniele Teixeira de Lemos2, Osmar Henrique Dos Santos Junior1
1Neuropsychiatry and Behavior Science Graduate Program, Federal University of Pernambuco - CAV, Vitória de Santo Antão, Brazil.
Physiology & behavior
|December 30, 2023
概括
在老鼠中早期的过度营养会损害大脑发育,增加肥胖风险. 氨酸治疗可以减轻这些负面影响,提供潜在的干预策略.
科学领域:
- 神经科学是一个神经科学.
- 代谢研究研究 代谢研究
- 发展生物学 发展生物学
背景情况:
- 儿童肥胖是一个日益严重的全球健康危机,具有重大经济影响.
- 生命的前1000天对于预防肥胖和相关健康问题至关重要.
- 迫切需要采取行动,以应对全球肥胖率的加快.
研究的目的:
- 研究哺乳期过度营养对细胞和分子标记物的直接影响.
- 检查血清激素调节在缓解早期营养过多的不良影响中的作用.
- 了解在前额叶皮层中过度营养的早期神经生物学后果.
主要方法:
- 使用了一个新生儿过度养的老鼠模型.
- 药理上使用的血清素调节剂 (选择性血清素再吸收抑制剂).
- 评估细胞功能,线粒体活动,氧化应激和基因表达.
主要成果:
- 过度养降低了NAD/NADH比率和酸盐合成酶活性,同时增加了活性氧物种 (ROS) 的产生.
- 在过度养的老鼠中观察到脂肪和蛋白质氧化的增加和抗氧化防御的减少.
- 选择性血清素再吸收抑制剂 (SSRI) 治疗抵消了过度营养的有害影响.
结论:
- 早期的营养过度严重影响在分子和细胞层面上前额叶皮质.
- 这些早期的变化可能会使个体倾向于与肥胖有关的神经退行功能障碍.
- 血清激素调节在预防早期过度营养的负面结果方面表现有前途.
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