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Updated: Jul 6, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

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在Gα-和β-arrestin2-介导的途径中,在人体基因素H3受体异型中以连体为导向的偏向性激素作用

Sabrina N Rahman1, Faissal Imhaouran2, Rob Leurs2

  • 1Drug Discovery Biology and Neuromedicines Discovery Centre, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, 3052 VIC, Parkville, Melbourne, Australia; Amsterdam Institute for Molecular Life Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.

Biochemical pharmacology
|December 30, 2023
PubMed
概括

基因组H3受体 (H3R) 药物开发需要了解其异型. 连接物偏差因H3R异形和途径而异,这对于选择性神经治疗至关重要.

关键词:
有偏见的激进主义.与G蛋白结合的受体 (GPCRs) 是一种连接物偏差 连接物偏差神经调节是一种神经调节.受体单元形式的受体.基因组胺 H(3) 受体 (H(3) R) 的发生.

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