循环中的细胞因子和患高血压的风险:系统性审查和元分析
Elisabetta Caiazzo1, Malvika Sharma2, Asma O M Rezig3
1School of Infection & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Pharmacological research
|December 30, 2023
概括
较高水平的互白素-6 (IL-6) 可能与发展高血压有关,但考虑到BMI等因素后,这种关联会减弱. 介素-1β (IL-1β) 没有显示出与高血压风险的显著联系.
科学领域:
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 免疫反应与高血压的发展有关.
- 特定的炎症媒介的作用,如细胞因子,需要进一步澄清.
- 这项研究调查了关键细胞因子和发生性高血压之间的关联.
研究的目的:
- 系统地审查和元分析关键细胞因子与高血压发病率之间的关联.
- 量化评估特定炎症媒介在高血压发病中的作用.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,CENTRAL) 进行系统的文献搜索,直到2022年8月.
- 包括同行评审的研究,将事件高血压定义为SBP ≥140 mmHg,DBP ≥90 mmHg,或使用抗高血压药物.
- 随机效应的元分析,以计算细胞因子水平 (最高与最低四分位数) 的聚合危险比率 (HRs) /风险比率 (RRs).
主要成果:
- 干白素-6 (IL-6) 被量化评估;最高四分位数与高血压风险增加有关 (HR/RR: 1.61).
- 在调整了像BMI这样的混因素后,IL-6和高血压之间的关联不再具有统计学意义 (HR/RR:1.24).
- 介素-1β (IL-1β) 在原始或调整分析中都没有显示出与高血压风险的显著关联.
结论:
- 较高的循环IL-6水平可能与高血压的发展有关,尽管这种联系被混因素减弱.
- IL-1β似乎与患高血压的风险没有显著关联.
- 需要进一步的研究才能充分阐明IL-6在高血压中的作用.
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