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Updated: Jul 6, 2025

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

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NOTCH2促进骨质细胞的成熟和新陈代谢,并在骨质细胞生成过程中调节转录组形状

Ernesto Canalis1, Lauren Schilling2, Jungeun Yu3

  • 1Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut, USA; Department of Medicine, UConn Health, Farmington, Connecticut, USA; UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut, USA.

The Journal of biological chemistry
|December 30, 2023
PubMed
概括

功能增强的NOTCH2通过增加骨髓衍生巨细胞 (BMM) 中的线粒体和代谢活性来增强骨质细胞形成. 这种效应与Hes1独立,并且在骨质细胞分化过程中影响细胞分配.

关键词:
哈吉杜·切尼综合症 (Hajdu Cheney Syndrome) 是一种疾病.这种受体是Notch受体.巨细胞是什么?巨细胞是什么?骨质细胞的骨质细胞.转录组 (transcriptome) 是一个转录组.

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