在使用SIB-VMAT进行放射治疗后患有头癌的患者中引起甲状腺功能低下的危险因素
Nahomi Yoshimura1, Masayuki Fujiwara2, Masataka Igeta3
1Department of Radiology, Hyogo Medical University, Hyogo, Japan.
Anticancer research
|December 30, 2023
概括
辐射诱导的甲状腺功能低下会影响超过三分之一的头癌患者接受SIB-VMAT治疗. 甲状腺剂量-体积参数,就像节省体积一样,是预防这种常见副作用的关键指标.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 内分泌学 在内分泌学.
背景情况:
- 接受放射治疗的头癌患者有辐射诱导的甲状腺功能低下的风险.
- 同时集成增强体积调制弧线疗法 (SIB-VMAT) 是用于头癌的常见放射治疗技术.
- 了解甲状腺功能低下的发病率和风险因素对于患者的管理至关重要.
研究的目的:
- 评估SIB-VMAT治疗的头癌患者中辐射诱导的甲状腺功能低下的发生率.
- 为了确定与甲状腺功能低下症发展相关的临床和剂量计风险因素.
- 探索辐射剂量-体积参数在预测这种并发症中的实用性.
主要方法:
- 在接受SIB-VMAT治疗的86名头癌患者的回顾性分析.
- 评估2级或更高的甲状腺功能低下症的发生率.
- 甲状腺功能低下症和临床因素之间的相关性分析,以及甲状腺剂量-体积参数 (例如,VS60,VS70,VS60EQD2,VS70EQD2).
主要成果:
- 36.0%的患者在17个月的中位随访期内发展出2级甲状腺功能低下症.
- 没有患者患有3级或更高的甲状腺功能低下症.
- 在甲状腺功能低下和甲状腺体积,VS60,VS70,VS60EQD2和VS70EQD2之间发现了显著的关联.
结论:
- 辐射诱导的甲状腺功能低下症是用SIB-VMAT治疗头癌患者的常见并发症.
- 甲状腺剂量-体积参数是预防辐射诱导的甲状腺功能低下症的有价值的预测指标.
- 进一步研究优化放射治疗计划以节省甲状腺是有必要的.
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