在年轻成年人中首次缺血性中风后的第一年认知轨迹:奥迪赛研究
Mijntje M I Schellekens1,2, Ravi C S Springer1, Esther M Boot1,2
1Neurology, Radboudumc, Nijmegen, The Netherlands.
Journal of neurology, neurosurgery, and psychiatry
|December 30, 2023
概括
在年轻的中风幸存者中常见的认知障碍是事件发生后的一年. 虽然大多数都没有变化,但有些人在处理速度,视觉构造和执行功能方面有所改善,但预测恢复仍然具有挑战性.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
背景情况:
- 关于年轻中风患者认知恢复的数据有限.
- 在年轻成年人中,中风发生一年后,认知障碍很普遍.
- 了解认知轨迹对于这一群体至关重要.
研究的目的:
- 为了研究年轻中风患者在第一年的认知表现的纵向过程.
- 在年轻成年人中确定缺血性中风后认知恢复的预测因素.
- 评估七个领域的认知变化.
主要方法:
- 一项多中心前性队列研究招募了393名年龄在18-49岁之间的患者,他们首次患有缺血性中风.
- 在中风后6个月内和1年内进行认知评估.
- 认知障碍是由Z-score<-1.5和可靠变化指数 (RCI) 的恢复/下降来定义的.
主要成果:
- 类似比例的患者表现出认知能力的改善和下降,大多数患者没有表现出任何变化.
- 在最初受损的患者中,在处理速度 (23.1%),视觉构造 (40.1%) 和执行功能 (20.0%) 方面有所改善.
- 年轻的年龄预测了更好的视觉结构恢复,较大的损伤体积预测了处理速度的恢复.
结论:
- 在年轻的中风幸存者中,认知障碍在一年后仍然存在.
- 虽然大多数患者没有显著的变化,但有些人在特定的认知领域经历了恢复.
- 预测个人的认知恢复仍然很困难,这凸显了进一步研究的必要性.
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