与iPad对儿科癌症治疗中疲劳的活性控制:一个随机对照试验
Tal Schechter1, Cassandra Tardif-Theriault2, Nicole Culos-Reed3
1Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
BMJ supportive & palliative care
|December 30, 2023
概括
在接受密集化疗的儿童中,个性化并没有显著减少一般疲劳. 然而,改善了这些年轻患者的认知疲劳和认知问题.
科学领域:
- 儿科瘤学 儿科瘤学
- 综合医学是一个整体的医学.
- 临床试验 临床试验
背景情况:
- 癌症治疗,包括化疗,往往导致儿童患者显著疲劳.
- 管理与治疗相关的副作用,如疲劳,对于改善癌症儿童的生活质量至关重要.
研究的目的:
- 评估个性化在接受强化化疗的住院儿童中减轻疲劳的有效性.
- 为了比较与iPad控制对各种疲劳指标的影响.
主要方法:
- 一个多中心随机对照试验,涉及接受密集化疗的儿科患者 (8-18岁).
- 参与者被随机分配到接受个性化的或iPad干预21天,5天/周.
- 主要结局是监护人报告的一般性疲劳,使用儿科生活质量库多维疲劳量表 (PedsQL MFS) 在第21天.
主要成果:
- 该试验在125名参与者注册后提前结束. 在和iPad组之间没有观察到一般疲劳的显著差异.
- 与对照组相比,干预导致认知疲劳和认知问题的显著改善.
- 在睡眠/休息疲劳或系统性阿片类药物管理方面,两组之间没有发现显著差异.
结论:
- 在接受密集化疗的儿科癌症患者中,针对整体疲劳的个性化的疗效仍然不确定.
- 在这个人群中,个性化在改善认知疲劳和解决认知问题方面表现出显著的好处.
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