对于来自不同来源的瘤,在射频除中使用外围T细胞子集
Yinghua Jin1, Qiuyu Zhao2, Chengjuan Fan3
1Department of Oncology, Dushu Lake Hospital Affiliated of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, Suzhou, China.
Asian journal of surgery
|December 30, 2023
概括
射频除 (RFA) 暂时影响了外围T细胞的反应,减少了特定的T细胞子集. 这些变化与接受RFA治疗的患者的瘤起源或肝炎状态无关.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 医疗程序 医疗程序
背景情况:
- 射频除 (RFA) 是一种已知会影响免疫细胞的癌症治疗方法.
- 了解RFA对T细胞免疫的影响对于优化癌症治疗至关重要.
研究的目的:
- 研究RFA对外围T细胞子集的影响.
- 为了确定RFA诱导的T细胞变化是否与瘤类型或肝炎状态相关.
主要方法:
- 对62名接受RFA治疗的患者进行了回顾性分析,用于治疗各种癌症.
- 流细胞计用于测量RFA之前和之后的外围T细胞子集.
- 分析与瘤起源和肝炎状态相关的T细胞子集变化.
主要成果:
- 在RFA后观察到CD4+CD8和CD4-CD8+T细胞子集的减少.
- 没有发现CD4+CD8+T细胞或CD4+CD8-/CD4-CD8+比率的显著变化.
- 根据瘤类型或肝炎状态,外围T细胞子集的变化没有显著差异.
结论:
- RFA治疗对外围T细胞群体具有短期影响.
- 观察到的T细胞子集变化独立于患者的瘤类型和肝炎状态.
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