在孕激素主导的卵巢刺激周期中,触发卵细胞检索间隔是否应该不同?
Baris Ata1, Aysu Cakar2, Engin Türkgeldi3
1Department of Obstetrics and Gynecology, Koc University School of Medicine, Istanbul, Turkey; ART Fertility Clinics, Dubai, United Arab Emirates; Assisted Reproduction Unit, Koc University Hospital, Istanbul, Turkey.
Reproductive biomedicine online
|December 31, 2023
概括
触发卵细胞检索间隔 (TORI) 不影响卵细胞成熟率不同于孕激素原始卵巢刺激 (PPOS) 和淋巴激素释放激素 (GnRH) 抗剂周期. 卵细胞成熟率在两种刺激方案中都是相似的,无论TORI.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
背景情况:
- 孕激素主导的卵巢刺激 (PPOS) 和性腺激素释放激素 (GnRH) 反对者协议是常见的卵巢刺激方法.
- 触发最终卵细胞成熟和卵细胞检索 (TORI) 之间的间隔是试管婴儿结果的关键因素.
- 了解TORI在不同刺激方案中对卵细胞成熟的影响对于优化试管婴儿成功至关重要.
研究的目的:
- 为了研究是否触发卵细胞检索间隔 (TORI) 不同地影响卵细胞成熟率在孕激素原始卵巢刺激 (PPOS) 与GnRH抗剂周期.
- 为了比较PPOS和GnRH抗剂协议之间的卵细胞成熟率,考虑TORI.
主要方法:
- 一项回顾性队列研究分析了473个GnRH抗剂周期和205个PPOS周期.
- 卵细胞成熟率被定义为二元期卵细胞的数量除以积卵细胞复合体的数量.
- 线性混合效应多变量回归评估了刺激方案和TORI在卵细胞成熟,控制年龄,触发型和刺激持续时间之间的相互作用.
主要成果:
- 固定PPOS (中位数80%),灵活PPOS (中位数75%) 和GnRH抗剂周期 (中位数75%) 的卵细胞成熟率相似.
- 在刺激方案 (PPOS与GnRH抗剂) 和TORI之间没有发现关于卵细胞成熟率的显著相互作用.
- 所有分析周期的TORI中位数为36.2小时,从33.6小时到39.1小时不等.
结论:
- 与GnRH对抗剂周期相比,孕激素主导的卵巢刺激 (PPOS) 周期不需要更长的触发器到卵细胞检索间隔 (TORI).
- 根据使用的刺激协议,TORI似乎不会对卵细胞成熟率产生不同的影响.
- 这些发现表明,对于PPOS和GnRH抗剂协议,TORI管理的灵活性与卵细胞成熟有关.
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