在第一发精神分裂症患者的幽默处理过程中,前叶的低和高激活
Bingjie Huang1, Chengcheng Pu1, Xiaodong Guo1
1Peking University Sixth Hospital, Beijing, China; Peking University Institute of Mental Health, Beijing, China; NHC Key Laboratory of Mental Health (Peking University), Beijing, China; National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
患有第一发精神分裂症 (FES) 的患者表现出幽默感受性降低. 脑部成像显示前额区域的低激活和部区域的过激活,与这些幽默处理缺陷有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 精神分裂症患者往往难以识别和欣赏幽默.
- 这些幽默缺陷的潜在神经机制尚不清楚.
研究的目的:
- 为了研究第一发精神分裂症 (FES) 患者的幽默处理的神经基质.
- 在FES中识别与幽默缺陷相关的大脑区域.
主要方法:
- 这项fMRI研究涉及40名FES患者和31名健康对照.
- 参与者评价了口头幽默刺激的有趣性.
- 信号检测理论 (SDT) 分析了幽默灵敏度 (d') 和响应标准 (β).
主要成果:
- 在FES患者中,幽默信号灵敏度显著降低 (d).
- 神经发现包括FES患者的腹中前额叶皮层 (vmPFC) 和前环皮层 (ACC) 的低激活.
- 与对照人群相比,在FES患者中,中圈 (MTG) 和上圈 (STG) 观察到过度激活.
- 在vmPFC/ACC中的活性与d'和β正相关;在FES患者中,STG活性与β正相关.
结论:
- 第一次精神分裂症的特点是对幽默信号的敏感性降低.
- 前额区域的低激活 (vmPFC,ACC) 和时区域的高激活 (MTG,STG) 与FES中的幽默处理缺陷有关.
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