硫酸多糖酸盐加快了gliadin的消化,并降低了其毒性
Lidia Kurochkina1, Denis Pozdyshev1, Mikhail Kusaykin2
1Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Biochemical and biophysical research communications
|December 31, 2023
概括
硫化海藻聚合物可以增强质蛋白质的消化,为乳病和质不耐受症提供潜在的新疗法. 这种方法可能会减少质.
科学领域:
- 生物化学 生化学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 病和质不耐受会对患者的生活质量产生负面影响,需要严格的无质饮食.
- 这些条件源于质前胺的蛋白酶耐药性,特别是质蛋白.
- 目前的管理依赖于饮食限制,突出了治疗替代品的需要.
研究的目的:
- 研究硫酸聚合物的潜力,以增强人类蛋白质酶的gliadin消化.
- 评估特定的硫酸多糖的有效性,包括来自棕色海藻的,在分解质蛋白质.
- 评估增强的gliadin消化对肠道细胞培养中的谷蛋白细胞毒性的影响.
主要方法:
- 测试了一组硫酸聚合物 (卡帕 - 卡拉基安南,德克斯硫酸盐,棕色海藻多糖,聚烯硫酸盐) 的小组.
- 评估了这些聚合物通过素和素激活质素消化的能力.
- 对Caco-2肠道上皮细胞的治疗gliadins的细胞毒性进行了评估.
主要成果:
- 一种来自Fucus evanescens的硫酸多糖化合物显著增强了小麦类蛋白质的蛋白质分解.
- 这种Fucus evanescens多糖还降低了类蛋白在Caco-2细胞上的细胞毒性.
- 其他测试的硫酸聚合物显示出不同程度的胺消化激活.
结论:
- 硫酸多糖,特别是来自Fucus evanescens的多糖,有望改善质消化.
- 这些聚合物可能为治疗乳病和质不耐受症提供一种新的治疗策略.
- 富科丹的无毒性支持其作为聚合物制药或食添加剂的发展.
相关概念视频
Oligosaccharide Assembly
2.9K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Multiple sugar molecules that may or may...
2.9K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334
Dipeptidyl Peptidase 4 Inhibitors
188
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
188
Drugs for Treatment of Ulcerative Colitis in IBD
144
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
144
Glycosaminoglycans
4.9K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
4.9K
Proteoglycans
3.9K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
3.9K


