在光线克罗恩病中的Infliximab血清度及其与疾病活性的关系:一个多中心横截面研究
Rodrigo Bremer Nones1, Eron Fabio Miranda2, Gustavo de Nardi Marçal2
1IBD Unit, Hospital Nossa Senhora das Graças, Curitiba, Brazil.
克罗恩病患者的血清Infliximab (IFX) 度与一般,内镜或实验室确认的活跃疾病与缓解相似. 然而,临床活跃的疾病显示IFX水平较低.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 监测血清Infliximab (IFX) 度对于优化克罗恩病 (CD) 治疗至关重要.
- 关于拉丁美洲IFX度监测的数据有限.
- 了解与疾病活动相关的IFX水平对于患者管理至关重要.
研究的目的:
- 为了比较患有活跃光线克罗恩病 (CD) 和缓解症患者之间的血清Infliximab (IFX) 度.
- 评估IFX最低水平与疾病活动的不同标志物之间的关系.
主要方法:
- 一项涉及80名光线CD患者的横截面研究,他们接受维持IFX治疗.
- 根据临床,内镜,放射学和实验室评估,患者被分为缓解或活跃疾病组.
- 测量了血清IFX的最低水平,并在两组之间进行了比较.
主要成果:
- 在缓解的患者 (5.63) 和一般活跃疾病的患者 (3.84) 之间,没有观察到血清IFX水平中位数的显著差异.
- 在疾病活动的内镜,放射学或实验室标志物中,IFX度没有显著差异.
- 在临床评估中发现了显著的差异,临床活跃疾病患者的IFX水平中位数较低 (2.14) 与缓解 (5.63) 患者相比.
结论:
- 在维持治疗期间的血清IFX度在光线CD患者中可比,这些患者经历了缓解或一般,内镜,放射和实验室疾病活动.
- 临床活跃的疾病与较低的血清INFLIXIMAB度有关,这表明在这个小组中可能需要调整剂量.
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