运动训练对ANGPTL3/8和ANGPTL4/8的影响及其与心脏代谢特征的关联
William G Hoffmann1, Yan Q Chen2, Charles S Schwartz3
1University of South Carolina School of Medicine, Columbia, SC, USA.
Journal of lipid research
|December 31, 2023
概括
定期运动可以降低有害的 ангиопоэтин样蛋白 (ANGPTL) 复合体3/8和4/8. 这些减少与改善的脂酶活性,脂质配置文件和降低心脏代谢风险因素相关,突出显示了一个关键的分子适应运动.
科学领域:
- 脂质代谢 脂质的代谢
- 运动生理学 运动生理学
- 心血管健康的心血管健康
背景情况:
- 血管蛋白样蛋白 (ANGPTL) 复合体3/8和4/8是脂蛋白脂酶 (LPL) 的关键抑制剂,也是失脂症的标.
- 定期炼对ANGPTL3/8和ANGPTL4/8水平和功能的影响仍然在很大程度上不明.
- 了解这些关系对于开发针对代谢障碍的基于运动的干预措施至关重要.
研究的目的:
- 与脂酶活动和心脏代谢特征相关的ANGPTL3/8和ANGPTL4/8的特征.
- 研究5个月的耐力运动训练干预对ANGPTL3/8和ANGPTL4/8.8的影响.
- 探索运动,ANGPTL复合体和代谢改善之间的分子机制.
主要方法:
- 分析来自HERITAGE家庭研究的642名成年人在5个月的耐力运动计划之前和之后的ANGPTL3/8和ANGPTL4/8水平.
- 在体内测量脂酶活性 (LPL,HL) 和心脏代谢风险因素.
- 相关性分析用于评估ANGPTL复合体,脂酶活动和代谢参数之间的关系.
主要成果:
- 较高的ANGPTL3/8和ANGPTL4/8基线水平与较差的脂质样本和心脏代谢健康有关.
- 耐力运动训练显著降低了ANGPTL3/8,与增加的LPL活动相关,HL活动降低,降低了甘油三,ApoB,内脏脂肪和禁食胰岛素.
- 运动诱导的ANGPTL4/8的变化与总胆固醇,LDL-C,apoB,HDL-triglycerides和胰岛素敏感度的改善相关.
结论:
- 运动诱导的ANGPTL3/8和ANGPTL4/8的减少与改善的脂酶功能,脂质谱和心脏代谢健康有关.
- ANGPTL3-4-8系统代表了一种潜在的分子途径,可以调解脂质代谢适应运动.
- 这些发现支持ANGPTL复合体作为治疗点,并强调运动作为脂质代谢的调节器.
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