ViCEKb:与白风相关的化学暴露体知识库
Nikhil Chivukula1, Kundhanathan Ramesh2, Ajay Subbaroyan1
1The Institute of Mathematical Sciences (IMSc), Chennai, India; Homi Bhabha National Institute (HBNI), Mumbai, India.
The Science of the total environment
|December 31, 2023
概括
环境中的化学物质可以引发白风. 我们创建了与白风相关的化学暴露体知识库 (ViCEKb),包含113种化学物质,其中许多在消费品中发现,以更好地了解白风的原因.
科学领域:
- 皮肤病学和毒理学
- 环境健康 环境健康
- 化学信息学 化学信息学
背景情况:
- Vitiligo 病原体涉及遗传和环境因素,但环境触发因素的了解很少.
- 现有的研究缺乏集中资源来识别与白风相关的化学物质.
- 了解化学物质暴露对于破译白风病病因至关重要.
研究的目的:
- 建立第一个关于白风触发化学物质的全面知识库,名为ViCEKb.
- 从已发表的文献中系统地选和编译已知的白风化学触发因素.
- 促进对白风环境原因的研究.
主要方法:
- 系统地手动整理科学文献以确定白风相关的化学物质.
- 在ViCEKb数据库中编译了113种独特的化学触发器.
- 化学信息学和转录学分析以探索化学性质和生物影响.
主要成果:
- ViCEKb含有113种独特的白风触发化学物质,根据证据和暴露来源进行分类.
- 已识别的化学物质如 Propyl gallate 和 Flutamide 在消费品和药物中常见,但缺乏皮肤敏感性调节.
- 化学信息学分析显示,与监管清单相比,ViCEKb中存在独特的化学支架,其中一些不受监管的化学物质具有很高的证据.
- 转录组学数据表明,常见的生物途径受到ViCEKb化学物质的影响.
结论:
- ViCEKb是了解白风中化学暴露体的宝贵资源.
- 这些发现强调了需要对消费品和药物中发现的某些化学物质进行监管.
- 这种知识库可以促进对白风复杂病因和环境触发因素的研究.
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